The anti-cancer potential of Melicope ptelefolia

Researchers have discovered that Melicope ptelefolia has great potential as an anti-cancer agent. This study, which was published in BMC Complementary and Alternative Medicine, evaluated the potential medicinal applications of M. ptelefolia by looking into its different properties.

• M. ptelefolia has been used in traditional medicine for various ailments. However, few studies have looked into the scientific rationale behind this.
• Dried and powdered young M. ptelefolia leaves were extracted sequentially using hexane, ethyl acetate, methanol, and water.
• To evaluate the antioxidant activity of M. ptelefolia extracts, ferric reducing antioxidant power (FRAP), 2,2?-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radicals scavenging and cellular antioxidant activity (CAA) assays were conducted.
• Anti-proliferative activity was evaluated through cell viability assay of four human cancer cell lines. These were HCC1937 and MDA-MB-231 for breast cancer, HCT116 for colorectal cancer, and HepG2 for liver cancer.
• Cell cycle, Annexin-V/7-aminoactinomycin D staining, and measurement of activation and inhibition of caspase enzymes were also done to validate the anti-proliferative activity.

The results of the experiment show that M. ptelefolia significant antioxidant, anti-proliferative, apoptosis induction, and cancer cell cycle inhibition activities. These suggest that M. ptelefolia can potentially be used for cancer therapy.

Read the full text of the study at this link.

Learn more about Melicope ptelefolia and other herbal remedies by visiting NaturalCures.news today.

Journal reference

Kabir MF, Ali JM, Abolmaesoomi M, Hashim OH. MELICOPE PTELEFOLIA LEAF EXTRACTS EXHIBIT ANTIOXIDANT ACTIVITY AND EXERT ANTI-PROLIFERATIVE EFFECT WITH APOPTOSIS INDUCTION ON FOUR DIFFERENT CANCER CELL LINES. BMC Complementary and Alternative Medicine. 05 May 2017; 17(252). DOI: 10.1186/s12906-017-1761-9